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Article

Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella.

Neuroscience research - 1 Aug 1999

Fukaya M, Yamada K, Nagashima M, Tanaka K, Watanabe M

Abstract excerpt

The glutamate transporter plays an important role in rapid removal of glutamate from the synaptic cleft. Glutamate transporter GLAST is highly expressed in the Bergmann glia (BG), a unipolar cerebellar astrocyte associated structurally and functionally with Purkinje cells (PCs). Here we investigated the expression and localization in the reeler and weaver mutant cerebella with disorganized cytoarchitecture and...

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Source

Identifiers

PMID: 10515259
DOI: 10.1016/s0168-0102(99)00052-8

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella.PMID 10515259Read ↗

Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells.Semantic proximity Read ↗

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Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.Semantic proximity Read ↗

From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.Semantic proximity Read ↗

GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes.Semantic proximity Read ↗

Phenotype, differentiation, and function differ in rat and mouse neocortical astrocytes cultured under the same conditions.Semantic proximity Read ↗

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann Glia for the functional synapse formationSemantic proximity Read ↗

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Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.Semantic proximity Read ↗

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