Article
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.
The European journal of neuroscience - 1 Mar 1998
Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K
Abstract excerpt
To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar Bergmann astrocytes, the mouse GLAST gene was inactivated. GLAST-deficient mice developed normally and could manage simple coordinated tasks, such as staying on a stationary or a slowly rotating rod, but fa...
Topics
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Amino Acid Transport System X-AG
- Animals
- Cerebellum
- Cold Temperature
- Electrophysiology
- Excitatory Postsynaptic Potentials
- Glutamic Acid
- In Vitro Techniques
- Membrane Potentials
- Mice
- Microscopy, Electron