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Article

Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.

The European journal of neuroscience - 1 Mar 1998

Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K

Abstract excerpt

To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar Bergmann astrocytes, the mouse GLAST gene was inactivated. GLAST-deficient mice developed normally and could manage simple coordinated tasks, such as staying on a stationary or a slowly rotating rod, but failed more challenging task such as staying on a quickly rotating rod. Electrophysiological examination revealed that...

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Identifiers

PMID: 9753165
DOI: 10.1046/j.1460-9568.1998.00108.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.PMID 9753165Read ↗

Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells.Semantic proximity Read ↗

Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella.Semantic proximity Read ↗

Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic ExcitotoxicitySemantic proximity Read ↗

From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.Semantic proximity Read ↗

Decreased expression of glutamate transporter GLAST in Bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.Semantic proximity Read ↗

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann Glia for the functional synapse formationSemantic proximity Read ↗

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.Semantic proximity Read ↗

Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4.Semantic proximity Read ↗

Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum.Semantic proximity Read ↗

[Generation of mice with glial cell dysfunction].Semantic proximity Read ↗

[Effects of GLAST gene knockout on phenotype and hearing in mice].Semantic proximity Read ↗

Altered phenotype of the vestibular organ in GLAST-1 null mice.Semantic proximity Read ↗

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