Host and Pathogen Copper-Transporting P-Type ATPases Function Antagonistically during Salmonella Infection

Abstract excerpt

ABSTRACT Copper is an essential yet potentially toxic trace element that is required by all aerobic organisms. A key regulator of copper homeostasis in mammalian cells is the copper-transporting P-type ATPase ATP7A, which mediates copper transport from the cytoplasm into the secretory pathway, as well as copper export across the plasma membrane. Previous studies have shown that ATP7A-dependent copper transport is...

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