Article
Copper resistance is essential for virulence of Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011
Wolschendorf Frank, Ackart David, Shrestha Tej B, Hascall-Dove Laurel, Nolan Scott, Lamichhane Gyanu, Wang Ying, Bossmann Stefan H, Basaraba Randall J, Niederweis Michael
Abstract excerpt
Copper (Cu) is essential for many biological processes, but is toxic when present in excessive amounts. In this study, we provide evidence that Cu plays a crucial role in controlling tuberculosis. A Mycobacterium tuberculosis (Mtb) mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold more Cu and was more susceptible to Cu toxicity than WT Mtb. Similar phenotypes were observed for a M....
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