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Concise Review: Prostate Cancer Stem Cells: Current Understanding

30 May 2018

Abstract excerpt

Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that...

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PMID: 29845679
DOI: 10.1002/stem.2859

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