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Article

Regenerative potential of prostate luminal cells revealed by single-cell analysis

30 Apr 2020

Abstract excerpt

Equal opportunity tissue regeneration Tissue regeneration is thought to be driven primarily by rare stem cells with distinctive properties. Single-cell RNA sequencing allows rigorous testing of this hypothesis. Karthaus et al. examined the regeneration of normal prostate tissue in mice after androgen ablation, a common treatment for prostate cancer (see the Perspective by Kelly). Unexpectedly, they found that in...

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PMID: 32355025
DOI: 10.1126/science.aay0267

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