Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.

PloS one - 1 Jan 2017

Akiyama Tokiho, Katsumura Takafumi, Nakagome Shigeki, Lee Sang-Il, Joh Keiichiro, Soejima Hidenobu, Fujimoto Kazuma, Kimura Ryosuke, Ishida Hajime, Hanihara Tsunehiko, Yasukouchi Akira, Satta Yoko, Higuchi Shigekazu, Oota Hiroki

Abstract excerpt

Humans show various responses to the environmental stimulus in individual levels as "physiological variations." However, it has been unclear if these are caused by genetic variations. In this study, we examined the association between the physiological variation of response to light-stimulus and genetic polymorphisms. We collected physiological data from 43 subjects, including light-induced melatonin suppression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melatonin

Share to Period Circadian Proteins

Share to Phylogeny

Share to Saliva

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28650999
DOI: 10.1371/journal.pone.0178373
PMCID: PMC5484468

Genes

PER2
PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.PMID 28650999Read ↗

Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3.Semantic proximity Read ↗

Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.Semantic proximity Read ↗

Phenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health.Semantic proximity Read ↗

How have our clocks evolved? Adaptive and demographic history of the out-of-African dispersal told by polymorphic loci in circadian genes.Semantic proximity Read ↗

Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection.Semantic proximity Read ↗

Genetic differences in human circadian clock genes among worldwide populations.Semantic proximity Read ↗

Understanding Chronotype: The Science of Our Internal ClocksSemantic proximity Read ↗

The Peripheral Clock Regulates Human PigmentationSemantic proximity Read ↗

Rigid Cooperation of Per1 and Per2 proteins.Semantic proximity Read ↗

Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS.Semantic proximity Read ↗

Human Peripheral Clocks: Applications for Studying Circadian Phenotypes in Physiology and PathophysiologySemantic proximity Read ↗

Genome-wide gene by environment study of time spent in daylight and chronotype identifies emerging genetic architecture underlying light sensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.