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Epigenetic adaptation of the placental serotonin transporter gene (SLC6A4) to gestational diabetes mellitus

26 Jun 2017

Abstract excerpt

We tested the hypothesis that gestational diabetes mellitus (GDM) alters the DNA methylation pattern of the fetal serotonin transporter gene (SLC6A4), and examined the functional relevance of DNA methylation for regulation of the SLC6A4 expression in the human placenta. The study included 50 mother-infant pairs. Eighteen mothers were diagnosed with GDM and 32 had normal glucose tolerance (NGT). All neonates were...

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PMID: 28650965
DOI: 10.1371/journal.pone.0179934

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