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Epigenome-wide and transcriptome-wide analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex

4 Aug 2015

Abstract excerpt

BACKGROUND: Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be set by anatomical and molecular alterations in the placenta associated with GDM. RESULTS: To assess the mechanistic aspects of fetal programming, we measured genome-wide methylation (Infinium...

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PMID: 26244062
DOI: 10.1186/s13148-015-0116-y

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