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Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

22 Feb 2018

Abstract excerpt

AIMS/HYPOTHESIS: We hypothesized that diabetes during pregnancy (DDP) alters genome-wide DNA methylation in placenta resulting in differentially methylated loci of metabolically relevant genes and downstream changes in RNA and protein expression. METHODS: We mapped genome-wide DNA methylation with the Infinium 450K Human Methylation Bead Chip in term fetal placentae from Native American and Hispanic women with...

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PMID: 29470513
DOI: 10.1371/journal.pone.0190698

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