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Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta

13 Nov 2022

Abstract excerpt

The offspring of mothers with gestational diabetes mellitus (GDM) are at a higher risk for metabolic dysregulation and neurodevelopmental impairment. Evidence suggests that serotonin, which is present in both the placenta and the brain, programs the development and growth of the fetal brain. In the current study, we tested the hypothesis that GDM affects the methylation of the serotonin transporter gene (SLC6A4)...

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PMID: 36431006
DOI: 10.3390/life12111869

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