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Article

Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.

International journal of obesity (2005) - 1 May 2019

Lillycrop Karen A, Garratt Emma S, Titcombe Philip, Melton Phillip E, Murray Robert J S, Barton Sheila J, Clarke-Harris Rebecca, Costello Paula M, Holbrook Joanna D, Hopkins James C, Childs Caroline E, Paras-Chavez Carolina, Calder Philip C, Mori Trevor A, Beilin Lawrie, Burdge Graham C, Gluckman Peter D, Inskip Hazel M, Harvey Nicholas C, Hanson Mark A, Huang Rae-Chi, Cooper Cyrus, Godfrey Keith M

Abstract excerpt

BACKGROUND: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. We tested the hypothesis that methylation of the SLC6A4 gene predicts adiposity across the life course. METHODS: DNA methylation at 5 CpGs within the SLC6A4 gene...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 30622309
DOI: 10.1038/s41366-018-0254-3
PMCID: PMC6522375

Genes

SLC6A4

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