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Article

Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2015

Umelo Ijeoma Adaku, Wever Olivier De, Kronenberger Peter, Noor Alfiah, Teugels Erik, Chen Gang, Bracke Marc, Grève Jacques De

Abstract excerpt

INTRODUCTION: Lung cancer remains the leading cause of cancer-related mortality worldwide, with metastatic disease frequently a prominent feature at the time of diagnosis. The role of NSCLC-derived EGFR mutations in cancer cell proliferation and survival has been widely reported, but little is known about the function of these mutations in invasive growth and metastasis. In this study, we sought to evaluate the...

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Source

Identifiers

PMID: 26342549
DOI: 10.1016/j.lungcan.2015.08.008

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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