Article
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity.
The Journal of biological chemistry - 5 Apr 2002
Mushtaq Adeel, Payton Mark, Sim Edith
Abstract excerpt
Arylamine N-acetyltransferases (NATs) are a homologous family of enzymes, which acetylate arylamines, arylhydroxylamines, and arylhydrazines by acetyl transfer from acetyl-coenzyme A (Ac-CoA) and are found in many organisms. NAT was first identified as the enzyme responsible for the inactivation of the anti-tubercular drug isoniazid in humans. The three-dimensional structure of NAT from Salmonella typhimurium has...
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