Article
The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2003
Bretsky Philip, Haiman Christopher A, Gilad Shlomit, Yahalom Joachim, Grossman Avital, Paglin Shoshana, Van Den Berg David, Kolonel Laurence N, Skaliter Rami, Henderson Brian E
Abstract excerpt
Deficiencies in tasks of detecting and repairing DNA damage lead to mutations and chromosomal abnormalities, a hallmark of cancer. The gene mutated in ataxia-telangiectasia (A-T), ATM, is a proximal component in performing such tasks. Studies of A-T families have suggested an increased risk of breast cancer among obligate female heterozygous carriers of ATM mutations. Paradoxically, studies of sporadic and...
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