Article
Detection of the Plasmodium falciparum Kelch-13 gene P553L mutation in sporozoites isolated from mosquito salivary glands in South-Central Vietnam.
Parasites & vectors - 24 Jun 2017
Maeno Yoshimasa, Quang Nguyen Tuyen, Culleton Richard, Kawai Satoru, Masuda Gaku, Hori Kaoru, Nakazawa Shusuke, Marchand Ron P
Abstract excerpt
BACKGROUND: Plasmodium falciparum has developed resistance against artemisinin in Southeast Asia. Mutations in the P. falciparum Kelch-13 (Pfk13) gene are associated with artemisinin resistance in vitro and in vivo. We investigated the prevalence of mutations in PfK13 from sporozoite-stage parasites isolated from the salivary glands of Anopheles dirus mosquitoes. METHODS: Mosquitoes were caught by human-landing...
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