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Article

Asn194Lys mutation in RVG29 peptide increases GFP transgene delivery by endocytosis to neuroblastoma and astrocyte cells.

The Journal of pharmacy and pharmacology - 1 Oct 2017

Villa-Cedillo Sheila Adela, Rodríguez-Rocha Humberto, Zavala-Flores Laura Mireya, Montes-de-Oca-Luna Roberto, García-García Aracely, Loera-Arias Maria de Jesus, Saucedo-Cárdenas Odila

Abstract excerpt

OBJECTIVES: A cell-penetrating peptide-based delivery system could target specific types of cells for therapeutic genes delivery. To increase the gene delivery efficiency into neuronal phenotype cells, we introduced an Asn194Lys mutation to RVG29 peptide derived from rabies virus glycoprotein and added a nuclear localization signal to enhance its nuclear import. METHODS: Mutant RVG or wild-type RVG peptide, a...

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PMID: 28643952
DOI: 10.1111/jphp.12766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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