Article

Engineering Brain Parasites for Intracellular Delivery of Therapeutic Proteins

2018-12-03

Abstract excerpt

Protein therapy has the potential to alleviate many neurological diseases; however, delivery mechanisms for the central nervous system (CNS) are limited, and intracellular delivery poses additional hurdles. To address these challenges, we harnessed the protist parasite Toxoplasma gondii, which can migrate into the CNS and secrete proteins into cells. Using a fusion protein approach, we engineered T. gondii to secr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb47e36d-3db0-5e85-8b77-1fbcbeaf1591
DOI: 10.1101/481192

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering Brain Parasites for Intracellular Delivery of Therapeutic ProteinsDOI 10.1101/481192Read

Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain.Semantic proximity Read

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during <i>Toxoplasma gondii</i> infectionSemantic proximity Read

Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii InfectionSemantic proximity Read

<i>Toxoplasma gondii</i> dissemination: a parasite's journey through the infected hostSemantic proximity Read

Transcriptional profiling reveals T cells cluster around neurons injected with <i>Toxoplasma gondii</i> proteinsSemantic proximity Read

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite PathogenesisSemantic proximity Read

Toxoplasma Effectors Targeting Host Signaling and TranscriptionSemantic proximity Read

A mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cellsSemantic proximity Read

Translocation of dense granule effectors across the parasitophorous vacuole membrane in <i>Toxoplasma</i> -infected cells requires the activity of ROP17, a rhoptry protein kinaseSemantic proximity Read

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene ExpressionSemantic proximity Read

Dense granule biogenesis, secretion, and function in Toxoplasma gondiiSemantic proximity Read

<i>Toxoplasma gondii</i> PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector exportSemantic proximity Read