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Article

An autonomous metabolic role for Spen.

PLoS genetics - 1 Jun 2017

Hazegh Kelsey E, Nemkov Travis, D'Alessandro Angelo, Diller John D, Monks Jenifer, McManaman James L, Jones Kenneth L, Hansen Kirk C, Reis Tânia

Abstract excerpt

Preventing obesity requires a precise balance between deposition into and mobilization from fat stores, but regulatory mechanisms are incompletely understood. Drosophila Split ends (Spen) is the founding member of a conserved family of RNA-binding proteins involved in transcriptional regulation and frequently mutated in human cancers. We find that manipulating Spen expression alters larval fat levels in a...

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Identifiers

PMID: 28640815
DOI: 10.1371/journal.pgen.1006859
PMCID: PMC5501677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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