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Article

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

13 Dec 2019

Abstract excerpt

Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF, regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents genomic instability. In addition, ARID1A has been shown to foster resistance to cancer therapy. By promoting non-homologous end joining (NHEJ), ARID1A enhances DNA repair. Consequently, ARID1A has been proposed as a promising therapeutic target to...

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PMID: 31847141
DOI: 10.3390/cancers11122014

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