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Article

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

1 Dec 2001

Abstract excerpt

Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive overexpression plays a key role in colon carcinogenesis. To understand the molecular nature of enhanced COX-2 expression detected in colon cancer, we examined the ability of the AU-rich element-containing (ARE-containing) 3' untranslated region (3'UTR) of COX-2 mRNA to regulate rapid mRNA decay in human colon cancer cells. In...

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PMID: 11733561
DOI: 10.1172/jci12973

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Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cellsPMID 11733561Read ↗

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