Article
Single-nucleotide polymorphisms in the human RAD21L gene may be a genetic risk factor for Japanese patients with azoospermia caused by meiotic arrest and Sertoli cell-only syndrome.
Human fertility (Cambridge, England) - 1 Sept 2017
Minase Gaku, Miyamoto Toshinobu, Miyagawa Yasushi, Iijima Masashi, Ueda Hiroto, Saijo Yasuaki, Namiki Mikio, Sengoku Kazuo
Abstract excerpt
Genetic mechanisms are implicated in some cases of male infertility. Recently, it was demonstrated that male mice lacking the gene for RAD21L exhibited azoospermia caused by meiotic arrest. Mouse RAD21L is a functionally relevant meiotic α-kleisin that is essential for male fertility. Therefore, we hypothesized that RAD21L mutations or polymorphisms may be associated with male infertility, especially azoospermia...
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