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Article

Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

Journal of assisted reproduction and genetics - 1 Aug 2011

Miyamoto Toshinobu, Tsujimura Akira, Miyagawa Yasushi, Koh Eitetsu, Namiki Mikio, Horikawa Michiharu, Saijo Yasuaki, Sengoku Kazuo

Abstract excerpt

PURPOSE: To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest. METHODS: Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls. RESULTS: The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001). CONCLUSION: The...

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Identifiers

PMID: 21573678
DOI: 10.1007/s10815-011-9576-y
PMCID: PMC3170112

Genes

UBR2

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