Mechanism and potential therapeutic strategies of genetic abnormalities involved in deoxyribonucleic acid double-strand breaks leading to the development of human non-obstructive azoospermia.

Abstract excerpt

BACKGROUND: Non-obstructive azoospermia (NOA) is a testicular or pre-testicular spermatogenic disorder characterized by severe impairment in sperm production due to testicular dysfunction. Whole-exome sequencing has identified mutations in several genes related to double-strand break (DSB) formation and repair in patients with NOA. In this review, we aimed to comprehensively elucidate the relationship between DSB...

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