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Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs.

Neuro-degenerative diseases - 1 Jan 2017

Krizova Jana, Stufkova Hana, Rodinova Marie, Macakova Monika, Bohuslavova Bozena, Vidinska Daniela, Klima Jiri, Ellederova Zdenka, Pavlok Antonin, Howland David S, Zeman Jiri, Motlik Jan, Hansikova Hana

Abstract excerpt

BACKGROUND: Huntington disease (HD) is a fatal neurodegenerative disorder involving reduced muscle coordination, mental and behavioral changes, and testicular degeneration. In order to further clarify the decreased fertility and penetration ability of the spermatozoa of transgenic HD minipig boars (TgHD), we applied a set of mitochondrial metabolism (MM) parameter measurements to this promising biological...

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PMID: 28633139
DOI: 10.1159/000475467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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