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Bioenergetics of human spermatozoa in patients with testicular germ cell tumours

1 Jan 2025

Abstract excerpt

In patients with testicular germ cell tumours (TGCT), sperm cryopreservation prior to anti-cancer treatment represents the main fertility preservation approach. However, it is associated with a low sperm recovery rate after thawing. Since sperm is a high-energy demanding cell, which is supplied by glycolysis and oxidative phosphorylation (OXPHOS), mitochondrial dysfunctionality can directly result in sperm...

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Share to Pediatric Urology and Nephrology Studies
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PMID: 40053689
DOI: 10.1093/molehr/gaaf005

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