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Article

The protein Dredd is an essential component of the c-Jun N-terminal kinase pathway in the Drosophila immune response.

The Journal of biological chemistry - 2 Sept 2011

Guntermann Silvia, Foley Edan

Abstract excerpt

The Drosophila immune deficiency (IMD) pathway mobilizes c-Jun N-terminal kinase (JNK), caspase, and nuclear factor-κB (NF-κB) modules to counter infection with gram-negative bacteria. Dredd is an essential caspase in the IMD pathway, and it is widely established that NF-κB activation depends on Dredd. More recent cell culture studies suggested a role for Dredd in the activation of dJNK (Drosophila JNK). However,...

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Identifiers

PMID: 21730059
DOI: 10.1074/jbc.M111.220285
PMCID: PMC3162387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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