Article
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.
Nature communications - 24 Jun 2022
Wang Fei, Ding Peiwen, Liang Xue, Ding Xiangning, Brandt Camilla Blunk, Sjöstedt Evelina, Zhu Jiacheng, Bolund Saga, Zhang Lijing, de Rooij Laura P M H, Luo Lihua, Wei Yanan, Zhao Wandong, Lv Zhiyuan, Haskó János, Li Runchu, Qin Qiuyu, Jia Yi, Wu Wendi, Yuan Yuting, Pu Mingyi, Wang Haoyu, Wu Aiping, Xie Lin, Liu Ping, Chen Fang, Herold Jacqueline, Kalucka Joanna, Karlsson Max, Zhang Xiuqing, Helmig Rikke Bek, Fagerberg Linn, Lindskog Cecilia, Pontén Fredrik, Uhlen Mathias, Bolund Lars, Jessen Niels, Jiang Hui, Xu Xun, Yang Huanming, Carmeliet Peter, Mulder Jan, Chen Dongsheng, Lin Lin, Luo Yonglun
Abstract excerpt
Pigs are valuable large animal models for biomedical and genetic research, but insights into the tissue- and cell-type-specific transcriptome and heterogeneity remain limited. By leveraging single-cell RNA sequencing, we generate a multiple-organ single-cell transcriptomic map containing over 200,000 pig cells from 20 tissues/organs. We comprehensively characterize the heterogeneity of cells in tissues and...
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