Article

Quantifying the effects of mutations on receptor binding specificity of influenza viruses

2010-01-01

Abstract excerpt

Hemagglutinin (HA) of influenza viruses is a cylindrically shaped homotrimer, where each monomer comprises two disulfide-linked subdomains HA1 and HA2. Influenza infection is initiated by binding of HA1 to its host cell receptors and followed by the fusion between viral and host endosomal membranes mediated by HA2. Human influenza viruses preferentially bind to sialic acid that is linked to galactose by an α2,6-li...

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Literature Corpus work: bdee4051-5dd0-5fef-b9ba-e7e25484d052
DOI: 10.4236/jbise.2010.33031

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