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Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4

1 Aug 2017

Abstract excerpt

Low-pathogenicity avian influenza viruses (LPAIVs) have caused a global concern to public health since the first novel LPAIV H7N9 outbreak occurred. The receptor-binding properties of the viral hemagglutinin are one key factor for efficient transmission and infection in humans. Recent evidence shows that H4 subtype viruses have been widely circulating in domestic poultry and human asymptomatic infections might...

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PMID: 28768203
DOI: 10.1016/j.celrep.2017.07.028

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