Article
The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma.
Diabetes - 1 Mar 2003
Sempoux Christine, Guiot Yves, Dahan Karin, Moulin Pierre, Stevens Martine, Lambot Virginie, de Lonlay Pascale, Fournet Jean-Christophe, Junien Claudine, Jaubert Francis, Nihoul-Fekete Claire, Saudubray Jean-Marie, Rahier Jacques
Abstract excerpt
Paternal mutation of ATP-sensitive K(+) (K(ATP)) channel genes and loss of heterozygosity (LOH) of the 11p15 region including the maternal alleles of ABCC8, IGF2, and CDKN1C characterize the focal form of persistent hyperinsulinemic hypoglycemia of infancy (FoPHHI). We aimed to understand the actual nature of FoPHHI in comparison with insulinoma. In FoPHHI, the lesion consists in clusters of beta-cells surrounded...
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