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Article

Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to ABCC8 and GCK mosaic mutations.

European journal of endocrinology - 1 Aug 2022

Boodhansingh Kara E, Yang Zhongying, Li Changhong, Chen Pan, Lord Katherine, Becker Susan A, States Lisa J, Adzick N Scott, Bhatti Tricia, Shyng Show-Ling, Ganguly Arupa, Stanley Charles A, De Leon Diva D

Abstract excerpt

Objective: Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in children. In addition to typical focal or diffuse HI, some cases with diazoxide-unresponsive congenital HI have atypical pancreatic histology termed Localized Islet Nuclear Enlargement (LINE) or mosaic HI, characterized by histologic features similar to diffuse HI, but confined to only a region of pancreas. Our...

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Identifiers

PMID: 35674212
DOI: 10.1530/EJE-21-1095
PMCID: PMC9339501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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