Article
Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation.
The Journal of allergy and clinical immunology - 1 May 2018
Walker Matthew T, Green Jeremy E, Ferrie Ryan P, Queener Ashley M, Kaplan Mark H, Cook-Mills Joan M
Abstract excerpt
BACKGROUND: Mechanisms for the development of food allergy in neonates are unknown but clearly linked in patient populations to a genetic predisposition to skin barrier defects. Whether skin barrier defects contribute functionally to development of food allergy is unknown. OBJECTIVE: The purpose of the study was to determine whether skin barrier mutations, which are primarily heterozygous in patient populations,...
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