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Article

Atg11 tethers Atg9 vesicles to initiate selective autophagy

29 Jul 2019

Abstract excerpt

Autophagy recycles cytoplasmic components by sequestering them in double membrane-surrounded autophagosomes. The two proteins Atg11 and Atg17 are scaffolding components of the Atg1 kinase complex. Atg17 recruits and tethers Atg9-donor vesicles, and the corresponding Atg1 kinase complex induces the formation of nonselective autophagosomes. Atg11 initiates selective autophagy and coordinates the switch to...

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PMID: 31356628
DOI: 10.1371/journal.pbio.3000377

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