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Article

Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.

PloS one - 1 Jan 2017

Sasaki Takashi, Mita Moeko, Ikari Naho, Kuboyama Ayane, Hashimoto Shuzo, Kaneko Tatsuya, Ishiguro Masaji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro

Abstract excerpt

TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases. We previously showed that nomilin, a citrus limonoid, activates TGR5 and confers anti-obesity and anti-hyperglycemic effects in mice. Information on the TGR5-nomilin interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28594916
DOI: 10.1371/journal.pone.0179226
PMCID: PMC5464637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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