Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer

2 Dec 2016

Abstract excerpt

Clear cell renal cell carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer therapeutic targets. Transcriptomic analysis of CCRCCs and matched microdissected renal tubular controls revealed overexpression of NOTCH ligands and receptors in tumor tissues. Examination of the TCGA RNA-seq data set also revealed widespread activation of NOTCH pathway in a large cohort of CCRCC samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Renal and related cancers
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27909050
DOI: 10.1074/jbc.m116.745208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal CancerPMID 27909050Read ↗

Genetic alteration in notch pathway is associated with better prognosis in renal cell carcinoma.Semantic proximity Read ↗

Clear cell renal cell carcinoma ontogeny and mechanisms of lethality.Semantic proximity Read ↗

Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology.Semantic proximity Read ↗

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.Semantic proximity Read ↗

Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the LiteratureSemantic proximity Read ↗

Integrated molecular analysis of clear-cell renal cell carcinoma.Semantic proximity Read ↗

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Multilevel Whole-Genome Analysis Reveals Candidate Biomarkers in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

The Role of Epigenetics in the Progression of Clear Cell Renal Cell Carcinoma and the Basis for Future Epigenetic TreatmentsSemantic proximity Read ↗

Recent progress in non-clear cell renal cell carcinoma: biology and therapeutic strategiesSemantic proximity Read ↗

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.