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Article

Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.

BMC biology - 21 Feb 2022

Palma-Vera Sergio E, Reyer Henry, Langhammer Martina, Reinsch Norbert, Derezanin Lorena, Fickel Joerns, Qanbari Saber, Weitzel Joachim M, Franzenburg Soeren, Hemmrich-Stanisak Georg, Schoen Jennifer

Abstract excerpt

BACKGROUND: Long-term selection experiments are a powerful tool to understand the genetic background of complex traits. The longest of such experiments has been conducted in the Research Institute for Farm Animal Biology (FBN), generating extreme mouse lines with increased fertility, body mass, protein mass and endurance. For >140 generations, these lines have been maintained alongside an unselected control line,...

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Identifiers

PMID: 35189878
DOI: 10.1186/s12915-022-01248-9
PMCID: PMC8862358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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