Article
The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome.
Molecular cell - 13 Jul 2012
Langlais David, Couture Catherine, Balsalobre Aurélio, Drouin Jacques
Abstract excerpt
Transcription factor recruitment to genomic sites of action is primarily due to direct protein:DNA interactions. The subsequent recruitment of coregulatory complexes leads to either transcriptional activation or repression. In contrast to this canonical scheme, some transcription factors, such as the glucocorticoid receptor (GR), behave as transcriptional repressors when recruited to target genes through protein...
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