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Article

One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.

Biophysical journal - 6 Jun 2017

Murata Agato, Itoh Yuji, Mano Eriko, Kanbayashi Saori, Igarashi Chihiro, Takahashi Hiroto, Takahashi Satoshi, Kamagata Kiyoto

Abstract excerpt

Tumor suppressor p53 slides along DNA and finds its target sequence in drastically different and changing cellular conditions. To elucidate how p53 maintains efficient target search at different concentrations of divalent cations such as Ca2+ and Mg2+, we prepared two mutants of p53, each possessing one of its two DNA-binding domains, the CoreTet mutant having the structured core domain plus the tetramerization...

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Identifiers

PMID: 28591603
DOI: 10.1016/j.bpj.2017.04.038
PMCID: PMC5474741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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