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Article

Transmembrane-domain determinants for SNARE-mediated membrane fusion.

Journal of cell science - 15 Jul 2010

Fdez Elena, Martínez-Salvador Mar, Beard Matthew, Woodman Philip, Hilfiker Sabine

Abstract excerpt

Neurosecretion involves fusion of vesicles with the plasma membrane. Such membrane fusion is mediated by the SNARE complex, which is composed of the vesicle-associated protein synaptobrevin (VAMP2), and the plasma membrane proteins syntaxin-1A and SNAP-25. Although clearly important at the point of membrane fusion, the precise structural and functional requirements for the transmembrane domains (TMDs) of SNAREs...

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Share to Membrane Fusion
Share to Microscopy, Fluorescence
Share to Multiprotein Complexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Multimerization

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Share to Synaptosomal-Associated Protein 25

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Source

Identifiers

PMID: 20571052
DOI: 10.1242/jcs.061325

Genes

VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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