Article
Evidence that electrostatic interactions between vesicle-associated membrane protein 2 and acidic phospholipids may modulate the fusion of transport vesicles with the plasma membrane.
Molecular biology of the cell - 1 Dec 2009
Williams Dumaine, Vicôgne Jérome, Zaitseva Irina, McLaughlin Stuart, Pessin Jeffrey E
Abstract excerpt
The juxtamembrane domain of vesicle-associated membrane protein (VAMP) 2 (also known as synaptobrevin2) contains a conserved cluster of basic/hydrophobic residues that may play an important role in membrane fusion. Our measurements on peptides corresponding to this domain determine the electrostatic and hydrophobic energies by which this domain of VAMP2 could bind to the adjacent lipid bilayer in an insulin...
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