Article
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
Journal of virology - 1 Apr 2007
Ehrhardt Christina, Wolff Thorsten, Pleschka Stephan, Planz Oliver, Beermann Wiebke, Bode Johannes G, Schmolke Mirco, Ludwig Stephan
Abstract excerpt
Recently we have shown that influenza A virus infection leads to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and that this cellular reaction is dependent on the expression of the viral nonstructural protein 1 (NS1). These data also suggested that PI3K activation confers a v...
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