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Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

6 Jun 2017

Abstract excerpt

Increased protein translation in cells and various factors in the tumor microenvironment can induce endoplasmic reticulum (ER) stress, which initiates the unfolded protein response (UPR). We have previously reported that factors released from cancer cells mounting a UPR induce a de novo UPR in bone marrow-derived myeloid cells, macrophages, and dendritic cells that facilitates protumorigenic characteristics in...

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PMID: 28588081
DOI: 10.1126/scisignal.aah7177

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