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Article

RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.

Molecular oncology - 1 Mar 2022

Scheiter Alexander, Evert Katja, Reibenspies Lucas, Cigliano Antonio, Annweiler Katharina, Müller Karolina, Pöhmerer Laura-Maria-Giovanna, Xu Hongwei, Cui Guofei, Itzel Timo, Materna-Reichelt Silvia, Coluccio Andrea, Honarnejad Kamran, Teufel Andreas, Brochhausen Christoph, Dombrowski Frank, Chen Xin, Evert Matthias, Calvisi Diego F, Utpatel Kirsten

Abstract excerpt

Aberrant activation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR and Ras/mitogen-activated protein kinase (MAPK) pathways is a hallmark of hepatocarcinogenesis. In a subset of hepatocellular carcinomas (HCCs), PI3K/AKT/mTOR signaling dysregulation depends on phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations, while RAS/MAPK activation is partly attributed to promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34748271
DOI: 10.1002/1878-0261.13135
PMCID: PMC8895452

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