Article
Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes.
Antimicrobial agents and chemotherapy - 1 Aug 2017
Blake Lynn D, Johnson Myles E, Siegel Sasha V, McQueen Adonis, Iyamu Iredia D, Shaikh Abdul Kadar, Shultis Michael W, Manetsch Roman, Kyle Dennis E
Abstract excerpt
Malaria-related mortality has slowly decreased over the past decade; however, eradication of malaria requires the development of new antimalarial chemotherapies that target liver stages of the parasite and combat the emergence of drug resistance. The diminishing arsenal of anti-liver-stage compounds sparked our interest in reviving the old and previously abandoned compound menoctone. In support of these studies,...
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