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Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

1 Dec 2011

Abstract excerpt

BACKGROUND: Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is critical for Treg cell growth, survival, and activity. We hypothesized that low-dose interleukin-2 could preferentially enhance Treg cells in vivo and suppress clinical manifestations of chronic GVHD. METHODS: In this observational cohort...

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PMID: 22129252
DOI: 10.1056/nejmoa1108188

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