Article
Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk.
European journal of internal medicine - 1 Jul 2017
Stegeman Bernardine H, Vos Hans L, Helmerhorst Frans M, Rosendaal Frits R, Reitsma Pieter H, van Hylckama Vlieg Astrid
Abstract excerpt
BACKGROUND: Use of ethinylestradiol, one of the active ingredients in combined oral contraceptives, affects the incidence of venous thrombosis. To explain why some women develop thrombosis when using oral contraceptives and others do not, we hypothesized a role for the first-pass metabolism of ethinylestradiol in the liver. We set out to determine the association between genetic variation in the first-pass...
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