Article
Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.
EBioMedicine - 1 Jun 2017
Matsuhashi Tetsuro, Sato Takeya, Kanno Shin-Ichiro, Suzuki Takehiro, Matsuo Akihiro, Oba Yuki, Kikusato Motoi, Ogasawara Emi, Kudo Tai, Suzuki Kosuke, Ohara Osamu, Shimbo Hiroko, Nanto Fumika, Yamaguchi Hiroaki, Saigusa Daisuke, Mukaiyama Yasuno, Watabe Akiko, Kikuchi Koichi, Shima Hisato, Mishima Eikan, Akiyama Yasutoshi, Oikawa Yoshitsugu, Hsin-Jung H O, Akiyama Yukako, Suzuki Chitose, Uematsu Mitsugu, Ogata Masaki, Kumagai Naonori, Toyomizu Masaaki, Hozawa Atsushi, Mano Nariyasu, Owada Yuji, Aiba Setsuya, Yanagisawa Teruyuki, Tomioka Yoshihisa, Kure Shigeo, Ito Sadayoshi, Nakada Kazuto, Hayashi Ken-Ichiro, Osaka Hitoshi, Abe Takaaki
Abstract excerpt
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favorable effects in the clinic. We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). MA-5 increased ATP, rescued...
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