Article

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD <sup>+</sup> and SIRT upregulation

2025-04-23

Abstract excerpt

<h4>SUMMARY</h4> Emerging evidence strongly supports a close relationship between age-related hearing loss and frailty, highlighting the importance of early detection and intervention. Recently, we invented a mitochondria-homing drug named mitochonic acid 5 (MA-5), that increases the adenosine triphosphate (ATP) levels, rescue mitochondrial function, and protect tissue damages. Currently, the phase I clinical tri...

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Literature Corpus work: 004cb063-49de-518d-9c4a-5674cc52db68
DOI: 10.1101/2025.04.18.649305

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