Article
Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.
Schizophrenia bulletin - 1 Mar 2010
O'Tuathaigh Colm M P, Kirby Brian P, Moran Paula M, Waddington John L
Abstract excerpt
Negative symptoms encompass diminution in emotional expression and motivation, some of which relate to human attributes that may not be accessible readily in animals. Additionally, their refractoriness to treatment precludes therapeutic validation of putative models. This review considers critically the application of mutant mouse models to the study of the pathobiology of negative symptoms. It focuses on 4 main...
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